Heart cells regrown using mRNA therapy in new mice study
Researchers used temporary mRNA expression to make heart cells multiply and heal after cardiac damage in mice.
Scientists can regrow heart cells after damage using a modified mRNA therapy, a new study in mice shows. Researchers used mRNA, the same technology behind some COVID vaccines, to temporarily activate two genes that trigger heart cell multiplication.
Activating these genes permanently actually harmed the heart, so the temporary approach was key. After simulated heart attack in mice, the therapy led to repair and restoration of heart function.
The finding could potentially lead to new heart failure treatments. The research was conducted in mice only; human trials would be needed before clinical use.
- About 50% 5-year mortality rate
- Heart failure survival
- Myc and cyclin T1
- Genes targeted
- Around 85% of cardiovascular deaths
- Proportion from MI and stroke
Why it mattersHeart failure is a leading cause of death worldwide. The ability to regrow heart cells could help save lives from cardiac damage.
AustraliaNo direct Australian effect yet, but heart disease kills thousands of Australians yearly, this research could eventually offer hope to heart patients.
